What do tests really tell breeders?
Click the title above if you’d like to learn more about the Canine diversity Project and how it relates to our Poodle population and check out the links below to read more specificly each topic
How to read a CERF evaluation:
What are DNA tests and are they reliable.
Progressive Retinal Atrophy (PRA):
Degenerative Myelopathy (DM): This is an autosomal recessive disease with a mutation in the SOD1-A Gene. It is adult-onset with ALS like symptoms: progressive limb weakness, muscle loss, tremors and stumbling developing into spinal and hind end paralysis. N/N= clear N/A=Carrier A/A= Affected
Von Willebrand’s Disease 1 (vWD1): This is an autosomal recessive disease characterized by low production of von Willebrand’s factor which is a key component in the clotting cascade. N/N= clear N/A=Carrier A/A= Affected
Neonatal Encephalopathy with Seizures (NEwS): This is an autosomal recessive developmental disease of the the brain. It has a very early onset presenting before 7 weeks with a zero percent survival rate. Affected puppies show progressive weakness, ataxia and ultimately seizures and death. N/N= clear N/A=Carrier A/A= Affected
More recently developed tests
Macrothrombocytopenia (MTC): This is an autosomal dominant disease with a mutation in the beta-1 tublulin gene causing the disease. It is characterized by low platelet values and the presence of giant platelets in the circulation. Unfortunately this form of thrombocytopenia doesn’t respond to treatment. N/N= clear N/A=Carrier A/A= Affected
Poodle Disease currently with no available screening